using niacin for lipids can increase homocysteine levels

New evidence shows that using niacin for lipids can increase homocysteine levels...a possible risk factor for heart disease.

Serum homocysteine levels can increase 17% with 1000 mg/day of niacin...55% for doses up to 3000 mg/day.

The concern is that increasing homocysteine might negate some of niacin's benefit from lowering cholesterol and triglycerides.

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