possible interaction between Aricept (donepezil) and Paxil (paroxetine)

February 2000

New reports suggest a possible interaction between Aricept (donepezil) and Paxil (paroxetine).

This is important. Alzheimer's patients commonly develop mood disorders that are treated with antidepressants.

Paxil is a potent cytochrome P450 2D6 inhibitor that may slow the metabolism of Aricept. Increased Aricept levels can lead to insomnia...confusion...severe diarrhea, etc.

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possible interaction between Aricept (donepezil) and Paxil (paroxetine)

Get concise, unbiased advice for effective drug therapy, plus CE/CME

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