New iPLEDGE Rules: What's Changing for Isotretinoin Rxs

October 2026

You’ll see updates to the iPLEDGE Risk Evaluation and Mitigation Strategy (REMS) for isotretinoin Rxs starting November 15, 2026.

Prescribers, patients, and pharmacies will still need to be enrolled with iPLEDGE...and ensure criteria to prevent pregnancy are met.

But look for several requirements to be rolled back...to try to ease the burden on patients and clinicians while maintaining safe use.

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