Start Low and Go Slow if Patients Switch to Methadone

April 2016

You'll see more caution about using methadone for chronic pain.

Only 2% of all opioid Rxs are for methadone...but it's involved in more than 30% of deaths from Rx opioids.

That's because of methadone's long and variable half-life, multiple interactions, risk of QT prolongation, etc.

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