Consider Pioglitazone for Patients with Prediabetes and Prior Stroke

You'll hear debate about using pioglitazone (Actos, etc) to decrease CV risk AFTER an ischemic stroke...in patients WITHOUT diabetes.

New evidence suggests pioglitazone may improve CV outcomes in patients with a prior stroke or TIA and insulin resistance or PREdiabetes.

Using pioglitazone for about 5 years prevents a second stroke or MI in 1 in 36 of these patients, and slows progression to diabetes in 1 in 26...but does not decrease overall mortality.

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