Think Twice Before Prescribing TMP/SMX With Potassium-Boosting Meds

January 2015

You'll hear more about possible harm when TMP/SMX (Bactrim, etc) is combined with meds that increase potassium (ACEIs, spironolactone, etc).

This interaction is more risky than previously thought...and is popping up on more drug interaction software.

Trimethoprim decreases urinary excretion of potassium.

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