Save Ezetimibe as an Add-On in High-Risk Patients

Controversy over the role of ezetimibe (Zetia, etc) and the pros and cons of aiming for LDL goals will heat up...again.

Ezetimibe fell out of favor several years ago...when a study showed that adding ezetimibe to simvastatin did NOT work better than simvastatin alone to slow atherosclerosis progression.

Now the big new "IMPROVE-IT" trial shows that adding ezetimibe to simvastatin 40 mg reduces CV events compared to simvastatin alone.

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