potentially fatal interaction between colchicine and some macrolides

October 2005

There are new concerns about a potentially fatal interaction between colchicine and some macrolides.

Erythromycin and clarithromycin (Biaxin) can INCREASE colchicine levels by inhibiting CYP3A4...and also P-glycoprotein.

CYP3A4 metabolizes colchicine to inactive metabolites.

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Table of Contents

a lot for all of us to learn from hurricanes Katrina and Rita
Diabetes Actos (pioglitazone) reduces the risk of heart attack, stroke, and death in some patients with type 2 diabetes
Infectious Diseases shorter five-day regimen of levofloxacin (Leva-pak) for acute bacterial sinusitis
Interactions potentially fatal interaction between colchicine and some macrolides
Dyslipidemia Omacor, the first PRESCRIPTION omega-3 fatty acid product
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