serotonin syndrome in patients taking fluoxetine (Prozac, etc) with the HIV drug ritonavir (Norvir, Kaletra).

There are reports of serotonin syndrome in patients taking fluoxetine (Prozac, etc) with the HIV drug ritonavir (Norvir, Kaletra).

Ritonavir is a potent inhibitor of cytochrome P450 enzymes... and can slow the metabolism of fluoxetine.

The combination can lead to symptoms of serotonin syndrome... confusion, muscle spasms, tremor, fever, anxiety, etc.

Get concise, unbiased advice for effective drug therapy, plus CE/CME

Prescriber's Letter includes:

  • 12 issues every year, with brief articles about new meds and guidelines
  • 48+ CE courses, including the popular CE-in-the-Letter
  • Quick reference drug comparison charts
  • Access to the entire archive

Already a subscriber? Log in

Volume pricing available. Get a quote