long-term warfarin might increase the risk of fractures

October 1999

There's a new concern that long-term warfarin might increase the risk of fractures.

Women who use warfarin for more than 12 months seem to have TWICE the risk of vertebral and rib fractures.

Chronic warfarin might decrease bone density by inhibiting vitamin K. Vitamin K plays a role in the production of osteocalcin...a protein that's important for bone formation.

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