High-dose ranitidine (Zantac) usually ISN'T more effective

April 1999

High-dose ranitidine (Zantac) usually ISN'T more effective than standard doses for gastroesophageal reflux disease (GERD).

Managed care organizations often recommend starting with ranitidine 150 mg BID for 6 to 8 weeks...then increasing the dose to 300 mg BID if symptoms persist.

But increasing the dose usually doesn't help. Fewer than half of patients have complete relief on either dose of ranitidine.

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