cytochrome P450 enzymes and their important role in causing drug interactions

May 1996

We get lots of calls about cytochrome P450 enzymes and their important role in causing drug interactions.

These enzymes are found primarily in the liver. They metabolize many drugs...nonsedating antihistamines...Prozac and other antidepressants...macrolide antibiotics...theophylline...warfarin, etc.

The cytochrome P450 enzymes are grouped into different families...CYP1, CYP2, CYP3, etc. These families are further subdivided into specific types...CYP2D6, CYP3A4, etc.

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