adding quinine to the list of drugs that shouldn't be used with the antihistamine Hismanal (astemizole)
May 1996
Janssen is adding quinine to the list of drugs that shouldn't be used with the antihistamine Hismanal (astemizole).
It'll be included in their "black box warning" in the package insert...along with ketoconazole, itraconazole, and erythromycin.
Quinine can increase levels of astemizole...possibly by inhibiting the metabolism of astemizole. This is serious...high levels of astemizole can prolong the QT interval and cause fatal arrhythmias.
Get concise, unbiased advice for effective drug therapy, plus CE/CME
Prescriber Insights: APRN includes:
- Cutting-edge advice about new medications and how they fit into practice
- Unbiased, evidence-based, 100% free of financial support from the pharma industry written by your peers
- Side-by-side comparisons of drugs by class or disease state, plus FAQs, pros/cons, and simple recommendations
Already a subscriber? Log in
Volume pricing available. Get a quote