Unpack the Evidence Behind Leucovorin for Autism and “CFD”

November 2025

Caregivers are asking about using leucovorin to treat autism.

We know po leucovorin (folinic acid) is FDA-approved to counteract methotrexate toxicity when treating cancer, autoimmune disorders, etc.

But FDA recently approved leucovorin tabs for patients with cerebral folate deficiency (CFD), stirring up questions about using it for autism.

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