Expect Questions About Cetirizine and Phenazopyridine Safety

July 2025

Recent news will bring up questions about some commonly used OTCs.

Cetirizine and levocetirizine. FDA is warning that sudden discontinuation of these second-generation antihistamines after prolonged use (few months to years) may cause rare but severe systemic pruritus.

Be ready with answers. While the mechanism of this “antihistamine withdrawal” is unclear, it seems more common with cetirizine than levocetirizine...and can occur in adults and kids at any dose.

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