CYP’n on Grapefruit Juice With Statins – Do We Still Avoid?

January 2025

There’s still debate about whether patients should really avoid certain statins with grapefruit juice.

Grapefruit juice is a notorious CYP3A4 inhibitor that interacts with over 85 drugs...including atorvastatin, simvastatin, and lovastatin.

We were taught to tell patients on these meds to avoid consuming grapefruit or its juice...due to concern for increased myopathy risk.

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