Consider the Best Role for Vancomycin AUC Dosing

November 2022

Questions about vancomycin AUC dosing continue to crop up.

Aiming for a trough of 15 to 20 mg/dL is a surrogate for obtaining an AUC over 400 mg*hr/L...which is the goal for efficacy.

But directly using an AUC goal of 400 to 600 mg*hr/L is linked to less acute kidney injury...likely from less vancomycin exposure.

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