Put the Aspirin and NSAID Interaction in Perspective
New data and talk of OTC label changes will reignite debate about whether NSAIDs reduce the CV protective effect of aspirin.
Many of us remember when FDA warned that ibuprofen may interact with aspirin. This is because aspirin binds to COX-1 to inhibit platelet aggregation...and nonselective NSAIDs can compete for the same receptor.
OTC ibuprofen labels even say it may decrease aspirin's CV benefit.