Don't Routinely Use Praluent for High Cholesterol

September 2015

Praluent (PRAL-you-ent, alirocumab) is the first "PCSK9 inhibitor" for high cholesterol.

It works by preventing PCSK9...proprotein convertase subtilisin kexin type 9...from binding and degrading liver LDL receptors. This leads to more LDL receptors...and more LDL cholesterol clearing from the blood.

Praluent can lower LDL by about 60%, regardless of statin use.

Get concise, unbiased advice for effective drug therapy, plus CE/CME

Prescriber's Letter includes:

12 issues every year, with brief articles about new meds and guidelines
48+ CE courses, including the popular CE-in-the-Letter
Quick reference drug comparison charts
Access to the entire archive

Subscribe Today!

Already a subscriber? Log in

Volume pricing available. Get a quote

Cardiology Save Entresto for Persistent Heart Failure Symptoms
Influenza Don't Automatically Give the Live Intranasal Vaccine to Kids
NSAIDs Limit NSAIDs in Patients With Cardiovascular Disease
Cardiology Don't Routinely Use Praluent for High Cholesterol
Pharmacogenetics Be Aware of Situations Where Pharmacogenetic Testing Makes Sense
Infectious Diseases Dispel the Myth That Discolored Nasal Mucus Always Means a Bacterial Infection
Gastroenterology Explain That Any Risk of Heart Attack With PPIs Is Very Small
Otics Consider Alternatives for Unapproved Otics
Stroke Don't Jump to Clopidogrel if Patients Have a GI Bleed on Aspirin
Antipsychotics Ensure Patients Get At Least 4 Months of Invega Sustenna BEFORE Invega Trinza
Lice Advise Reapplying Nix in 7 to 10 Days Even if Labels Say Otherwise
Sleep Disorders Don't Use Hetlioz for Most Insomnia Patients

Don't Routinely Use Praluent for High Cholesterol

Get concise, unbiased advice for effective drug therapy, plus CE/CME

Table of Contents