Don't Let PCSK9 Inhibitors Steer You Away From Statins

August 2015

You'll hear buzz about "PCSK9 inhibitors" for high cholesterol, Praluent (PRAL-you-ent, alirocumab) and Repatha (rih-PATH-ah, evolocumab).

These monoclonal antibodies will be the first biologics injected subcutaneously once or twice a month for high LDL cholesterol.

They prevent the protein PCSK9...proprotein convertase subtilisin kexin type 9...from binding and degrading liver LDL receptors. This leads to more LDL receptors...and more LDL cholesterol clearing from the blood.

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