the best way to calculate creatinine clearance (CrCl) for dosing renally eliminated drugs

November 2013

Questions often come up about the best way to calculate creatinine clearance (CrCl) for dosing renally eliminated drugs.

The Cockcroft-Gault equation is still the preferred method...and is what drug manufacturers use to determine renal dosing.

But it was developed using mostly "average" men...healthy, middle-aged, and about 70 kg.

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Table of Contents

Cardiology bigger emphasis on preventing hospital admissions for heart failure
Diabetes Experts will debate whether gliptins (Onglyza, etc) increase cardiovascular risk in patients with type 2 diabetes
Women's Health Reps will promote Brisdelle (BRIS-del) as a new nonhormonal treatment for hot flashes
Substance Use Disorder new approaches to managing alcohol dependence
Antithrombotics how to manage antiplatelet therapy in patients already taking anticoagulants
Pregnancy more questions about which cough, cold, and allergy meds to use during pregnancy and breastfeeding
Renal & Urology the best way to calculate creatinine clearance (CrCl) for dosing renally eliminated drugs
Contraceptives The new Minastrin 24 Fe and Lo Minastrin Fe (min-NASS-trin, norethindrone/ethinyl estradiol) are causing lots of confusion
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Pediatrics many parents exhibit signs of "fever phobia" and overuse antipyretics in their kids