Does it ever make sense to dose extended-release metformin or basal insulin twice daily

November 2012

Does it ever make sense to dose extended-release metformin or basal insulin twice daily?

Yes, sometimes. Giving these diabetes meds twice a day instead of once can decrease adverse effects...or increase efficacy.

Extended-release metformin dosing can be split and given BID if once-daily dosing causes too much GI upset.

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