the interaction between simvastatin (Zocor, etc) and amlodipine (Norvasc, etc)

September 2011

New alerts will raise new questions about the interaction between simvastatin (Zocor, etc) and amlodipine (Norvasc, etc).

Some prescribers are surprised...because amlodipine is only a weak inhibitor of simvastatin metabolism by CYP3A4 enzymes.

But the combo IS associated with a higher risk of myopathy.

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