Zyrtec ads that warn against taking Allegra with orange juice are raising questions about a new kind of fruit juice interaction

Zyrtec ads that warn against taking Allegra with orange juice are raising questions about a new kind of fruit juice interaction.

Orange, grapefruit, and apple juice can DECREASE absorption of fexofenadine (Allegra, etc) and other drugs in the gut.

Drinking 300 mL of orange or grapefruit juice with fexofenadine can reduce blood levels by about 40%...and MIGHT make it less effective.

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