how genetic variations and drug interactions may decrease the efficacy of clopidogrel (Plavix)

New labeling will focus on how genetic variations and drug interactions may decrease the efficacy of clopidogrel (Plavix).

These factors can lead to less efficient CYP2C19 metabolism...one of the main enzymes that convert clopidogrel to its active form.

Genetics. About 30% of whites and blacks and over 50% of Asians have variations that decrease clopidogrel metabolism. This might translate to a higher risk for cardiac events.

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