rhabdomyolysis in patients taking both simvastatin and amiodarone (Cordarone, etc)

You'll hear more about rhabdomyolysis in patients taking both simvastatin and amiodarone (Cordarone, etc).

FDA is getting increasing reports on this...even though the product labeling has warnings about muscle injury with this combo.

Amiodarone inhibits CYP3A4, which increases concentrations of simvastatin...lovastatin...and to a lesser extent, atorvastatin.

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