proton pump inhibitors (PPIs) might decrease the antiplatelet effects of clopidogrel (Plavix)

November 2008

For updated information on this topic, please see Detail-Document #250401

Aetna is sending out an alert that proton pump inhibitors (PPIs) might decrease the antiplatelet effects of clopidogrel (Plavix).

They suggest not using a PPI with clopidogrel unless there is a high risk of GI bleeding.

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