The interaction between warfarin and oral corticosteroids now seems more significant than previously thought

April 2007

The interaction between warfarin and oral corticosteroids now seems more significant than previously thought.

Many references list this as low severity...or not at all.

But many warfarin patients have an INCREASE in INR when they start prednisone or methylprednisolone...possibly due to inhibition of warfarin metabolism through CYP3A4 enzyme competition.

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