statins decrease the effects of Plavix

January 2003

You might hear that statins decrease the effects of Plavix.

Plavix (clopidogrel) is converted to its ACTIVE form through cytochrome P450 3A4 metabolism.

Since Lipitor, Zocor, and lovastatin are all metabolized by cytochrome P450 3A4, researchers theorize that Plavix and these statins might compete...and therefore reduce the effects of Plavix.

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