caffeine might reduce the efficacy of methotrexate for rheumatoid arthritis

April 2003

There's concern that caffeine might reduce the efficacy of methotrexate for rheumatoid arthritis.

Methotrexate decreases inflammation by increasing adenosine levels. Caffeine might interfere because it's an adenosine ANTAGONIST.

Now a small study shows that patients who consume more caffeine get less benefit from methotrexate than those who consume less.

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