reduce the dose of Pepcid even in patients with MODERATE renal impairment

May 2001

There's now a new warning to reduce the dose of Pepcid even in patients with MODERATE renal impairment.

Pepcid is excreted renally. A lower dose is already recommended for SEVERE renal insufficiency...creatinine clearance < 10 mL/min.

Now Merck also recommends lowering the dose for patients with MODERATE renal insufficiency...creatinine clearance < 50 mL/min.

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