how long they have to avoid grapefruit juice if they take certain drugs

October 2000

Patients often ask how long they have to avoid grapefruit juice if they take certain drugs.

Grapefruit juice can increase the absorption of many drugs... lovastatin, simvastatin, triazolam, diazepam, some calcium blockers, etc.

Grapefruit juice inactivates cytochrome P450 3A4 in the gut.It can take 3 DAYS or longer for enzyme activity to recover.

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