St. John's wort interacts with digoxin
New evidence suggests that St. John's wort interacts with digoxin. It seems to lower digoxin serum concentrations about 25%.
Researchers suspect that St. John's wort reduces digoxin absorption...possibly by inducing P-glycoprotein in the gut.
P-glycoprotein helps eliminate drugs in the intestine and kidney. It works by transporting drugs OUT of cells...into the gut lumen or renal tubule for excretion.