Manage Dose Adjustments in Liver Disease

You’ll need strategies to adjust med doses in patients with liver impairment...since med labels often lack clear recommendations.

Most meds don’t need dose adjustments until liver function is at least 90% impaired...such as in patients with decompensated cirrhosis who have jaundice or variceal bleeding.

We know liver enzymes (ALT, AST) are just a marker of hepatic injury...not how well the liver is functioning. In fact, these labs may be normal in a patient with advanced cirrhosis.

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