Add DOACs to Your List of Options for Treating HIT

You'll get questions about using direct oral anticoagulants (DOACs) for heparin-induced thrombocytopenia (HIT).

We usually treat HIT with IV argatroban...or sometimes IV bivalirudin or subcutaneous fondaparinux. Then we transition to warfarin once the platelet count recovers...usually 150,000/mm³ or higher.

Now there's growing interest in using a DOAC to treat HIT. But data are limited, especially when considering DOACs as initial HIT treatment.