Adding topiramate to phentermine increases weight loss.
Some prescribers are writing for phentermine plus topiramate (Topamax) for weight loss.
There’s even a phentermine and extended-release topiramate combo in the pipeline called Qnexa.
Phentermine is modestly effective short-term for suppressing appetite. The antiseizure drug topiramate also decreases appetite...and possibly also inhibits lipid formation.