Taking aspirin at bedtime LOWERS blood pressure.
Patients who take aspirin 100 mg at bedtime can see a drop of about 6/4 points in systolic/diastolic blood pressure. But taking the same dose in the morning does NOT give this same benefit.
This may seem counterintuitive since we associate NSAIDs with decreased renal function, edema, and increased blood pressure.
Aspirin inhibits the powerful vasoconstrictor angiotensin II...which is most active at night. This might explain the dip in BP.