Long-term treatment with bisphosphonates INCREASES the risk of fractures.
See updated information from the FDA concerning bisphosphonates and increased risk of thigh bone fracture
There are several reports of unusual fractures that occur from minimal trauma in patients on long-term or high-dose bisphosphonates.
A woman is suing Merck...claiming that alendronate (Fosamax) caused multiple stress fractures in her legs.
Bisphosphonates work by inhibiting bone breakdown. The concern is that they might OVER-suppress bone turnover...and delay healing of microcracks that occur normally with daily activities.