strategies for managing treatment-resistant depression

New evidence will improve strategies for managing treatment-resistant depression. More than HALF of patients continue to have symptoms after initial treatment for depression.

Switching to a different antidepressant is helpful in about 25% of patients who don't respond to an SSRI.

Changing classes isn't always necessary. For example, patients who don't respond to citalopram (Celexa) are as likely to respond to sertraline (Zoloft) as they are to venlafaxine (Effexor XR) or bupropion (Wellbutrin SR).

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