Rifampin plus pyrazinamide is no longer recommended for latent tuberculosis

Rifampin plus pyrazinamide is no longer recommended for latent tuberculosis...due to concerns about hepatotoxicity.

This combo was added to the TB recommendations in 2000.

Its advantage is that it can be given for only 2 to 3 months...compared to 4 to 9 months for the other drug regimens.

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