whether patients on Prozac or another SSRI can use one of the "triptans" for migraines

December 1999

The question often comes up about whether patients on Prozac or another SSRI can use one of the "triptans" for migraines...Imitrex (sumatriptan), Zomig (zolmitriptan), Maxalt (rizatriptan), or Amerge (naratriptan).

This is very important because many migraine patients take antidepressants to prevent headaches...or for another condition.

The big concern is that combining a triptan with an SSRI might lead to serotonin syndrome...due to additive serotonergic effects.

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