Single or intermittent doses of fluconazole DON’T cause significant drug interactions.

This is mostly true...but there are some situations to watch for.

Single-dose and intermittent fluconazole regimens are popular for vaginal yeast infections...they’re less messy than OTC options.

But fluconazole is a strong inhibitor of CYP2C19...and a moderate inhibitor of CYP3A4 and 2C9 enzymes.

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