Cymbalta is better than Effexor XR for depression.
January 1
Both Cymbalta (duloxetine) and Effexor XR (venlafaxine) are dual-uptake inhibitors. They inhibit the reuptake of serotonin AND norepinephrine.
Cymbalta is often touted as possibly being more efficacious and better tolerated than Effexor XR.
This is because duloxetine is a more "balanced" reuptake inhibitor...whereas venlafaxine primarily affects serotonin at lower doses and hits norepinephrine at higher doses.
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