Maximize Beta-Blockers Before Starting Ivabradine

June 2015

Ivabradine (Corlanor, CORE-lah-nore) will be the first new drug approved for systolic heart failure in a decade.

It works by inhibiting the If or "funny" current in the sinoatrial node. This lowers heart rate...withOUT causing a drop in blood pressure.

Ivabradine prevents 1 in 25 patients from being hospitalized over 2 years...when ADDED to standard therapy including an ACEI or ARB, beta-blocker, and aldosterone antagonist. But it DOESN'T reduce overall mortality.

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