Watch for Direct Oral Anticoagulant (Pradaxa, etc) Drug Interactions

May 2016

You'll see drug interaction alerts pop up with direct oral anticoagulants (DOACs) such as Pradaxa (dabigatran).

We know interactions are less common with DOACs than warfarin.

But Eliquis (apixaban) and Xarelto (rivaroxaban) are metabolized by CYP3A4...and absorption of all 4 DOACs is affected by P-glycoprotein.

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Table of Contents

Opioids Limit Opioids for Acute Pain...to Decrease Risk of Long-Term Use
Cardiology Talk to More Primary Prevention Patients About the Benefits and Risks of Statins
Metformin Don't Routinely Check B12 Levels in Most Patients Taking Metformin
Diabetes Caution Flozin Patients to Stay Well Hydrated While Fasting
Anticoagulants Watch for Direct Oral Anticoagulant (Pradaxa, etc) Drug Interactions
Vaccines Give Zostavax at Age 60 Instead of Age 50
Parasitic Infections Stick With Pyrantel Pamoate for Pinworms
Depression Consider Adding a Short-Term Stimulant for Some Seniors With Depression
Supplements Watch for Supplements that Increase Bleeding with Warfarin or DOACs
Infections Don't Worry Too Much About Pseudomonas Coverage for Diabetic Foot Infections
Med Administration Dispel Rumors Doxycycline Can't Be Taken With Milk
Practice Metformin labeling is catching up with the evidence