Watch for Hypoglycemia in Patients Taking Repaglinide Plus Clopidogrel

October 2015

You'll hear about a potentially dangerous interaction between clopidogrel (Plavix, etc) and repaglinide (Prandin, etc).

We usually think of clopidogrel as a CYP2C19 substrate. But clopidogrel also INHIBITS CYP2C8...causing repaglinide levels to increase.

In fact, clopidogrel can raise repaglinide levels by over 5-fold...and may lead to significant hypoglycemia.

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Table of Contents

Cardiology Help Patients Stick With a Statin...Instead of the New PCSK9 inhibitors
Anticoagulants Use a Checklist to Monitor Patients on DOACs
Testosterone Educate Men About Risks of Testosterone for "Low T"
Women's Health Pick Your Go-To Oral Contraceptive to Simplify Choices
HIV & AIDS Avoid Some HIV Drugs With Simvastatin or Lovastatin
Oral Health Don't Use Antibiotics Before Dental Work for Prosthetic Joint Patients
Biosimilars Explain That Biosimilars are not Exact Generic Equivalents
Vaccines Be Aware that Bexsero and Trumenba Only Protect Against Meningitis B
Substance Use Disorder Be Alert to Unexpected Drugs of Abuse...Such as Bupropion
Diabetes Listen for Gliptin Patients Complaining of Severe Joint Pain
Sexual Dysfunction Don't Use Addyi for Many Women With Sexual Dysfunction
Interactions Watch for Hypoglycemia in Patients Taking Repaglinide Plus Clopidogrel