dextromethorphan for pain

Some physicians are prescribing dextromethorphan for enhance the analgesic effect of opioids such as morphine.

We usually think of dextromethorphan (DM) as a coughsuppressant...but it's chemically similar to opioids. It's thedextro isomer of the codeine analog, levorphanol.

Dextromethorphan reduces sensitivity to pain by blocking NMDA(N-methyl-D-aspartate) receptors in the brain and spinal cord. Thishelps increase and prolong the analgesic effect of opioids.

Get concise, unbiased advice for effective drug therapy, plus CE/CME

Prescriber's Letter includes:

  • 12 issues every year, with brief articles about new meds and guidelines
  • 48+ CE courses, including the popular CE-in-the-Letter
  • Quick reference drug comparison charts
  • Access to the entire archive

Already a subscriber? Log in

Volume pricing available. Get a quote