dextromethorphan for pain

April 1998

Some physicians are prescribing dextromethorphan for pain...to enhance the analgesic effect of opioids such as morphine.

We usually think of dextromethorphan (DM) as a coughsuppressant...but it's chemically similar to opioids. It's thedextro isomer of the codeine analog, levorphanol.

Dextromethorphan reduces sensitivity to pain by blocking NMDA(N-methyl-D-aspartate) receptors in the brain and spinal cord. Thishelps increase and prolong the analgesic effect of opioids.

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dextromethorphan for pain

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