Accolate (zafirlukast) for asthma

Zeneca will soon introduce Accolate (zafirlukast) for asthma. It's the first drug in a brand-new class of asthma meds.

Accolate is a leukotriene receptor antagonist (LTRA). Leukotrienes have been a HUGE area for asthma research...this discovery resulted in a Nobel prize.

Leukotrienes are pro-inflammatory substances. They're released from mast cells when exposed to allergens. In the lung they can trigger bronchoconstriction...inflammation...edema...mucus secretion...and recruit inflammatory cells such as eosinophils.

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